SVJ and SEJ: conceptualized and built the study and drafted the manuscript. SEJ supplied supervision. The two authors critically reviewed, edited and accepted the final Model in the manuscript.

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(B) The toxicological profile of the new tobacco product related to the route of administration, including the genotoxicity, carcinogenicity, reproductive toxicity, immunotoxicity, acute toxicity, and repeat dose (Long-term) toxicity of the new tobacco merchandise relative to other tobacco items. The toxicological profile also features info on the toxicity from the substances, additives, and HPHCs, relative into the route of administration as well as number of prospective levels of publicity ensuing from using, or exposure to, The brand new tobacco product or service, which include scientific studies which go over the toxicological consequences of any leachables and extractables that could show up through the container closure process along with the component combination, for example additive or synergistic outcomes;

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“These closing regulations will supply bigger clarity and performance in critique of new tobacco merchandise by describing data that any corporation will have to provide should they search for to current market a brand new tobacco product in this state.”

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(K) Comprehensive descriptions of any using tobacco or aerosol-creating regimens employed for analytical tests that are not standardized or greatly accepted with the scientific Local community, if relevant.